Joiner Lab

Publications by William Joiner (* co-first author but listed second)


Joiner, W.J. Unraveling the evolutionary determinants of sleep. Curr Biol. 26, R1073–R1087, 2016.

Barekat, A., Gonzalez, A., Mauntz, R.E., Kotzebue, R.W., Molina, B., El-Macharrafie, N., Conner, C.J., Garza, S., Melkani, G.C., Joiner, W.J., Lipinski, M.M., Finley, K.D., and Ratliff, E.P. Using Drosophila as an integrated model to study mild repetitive traumatic brain injury. Sci Rep 6, 25252, 2016.

Landgraf, D., Joiner, W.J., McCarthy, M.J., Kiessling, S., Barandas, R., Young, J.W., Cermakian, N., and Welsh, D.K. The Mood Stabilizer Valproic Acid Opposes the Effects of Dopamine on Circadian Rhythms. Neuropharmacology 107, 262-270, 2016.

Wu, M., Liu, C.Z., and Joiner, W.J. Structural analysis and deletion mutagenesis define regions of QUIVER/SLEEPLESS that are responsible for interactions with Shaker-type potassium channels and nicotinic acetylcholine receptors. Plos One 11: e0148215, 2016.

Robinson, J.E., Paluch, J., Dickman, D.K., and Joiner, W.J. ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity.

Nat Commun. 7:10512, 2016. PMCID: PMC4737855.


Seidner, G.A., Robinson, J.E., Wu, M., Worden, K., Masek, P., Roberts, S.W., Keene, A.C., and Joiner, W.J. Identification of neurons with a privileged role in sleep homeostasis in Drosophila melanogaster. Curr Biol. 25, 2928-2938, 2015. PMCID: PMC4654679.

Wu, M., Puddifoot, C.A., Taylor, P., and Joiner, W.J. Mechanisms of Inhibition and Potentiation of α4β2 Nicotinic Acetylcholine Receptors by Members of the Ly6 Protein Family. J. Biol. Chem. 290, 24509-18, 2015. PMCID: PMC4591831.

Zhang, S., Ross, K.D., Seidner, G.A., Gorman, M.R., Poon, T.H., Wang, X., Keithley, E.M., Lee, P.N., Martindale, M.Q., Joiner, W.J., and Hamilton, B.A. Nmf9 encodes a highly conserved protein important to neurological function in mice and flies. PLoS Genet. 11, e1005344, 2015. PMCID: PMC4488434.

Ratliff, E.P., Mauntz, R.E., Kotzebue, R.W., Gonzalez, A., Achal, M., Barekat, A., Finley, K.A., Sparhawk, J.M., Robinson, J.E., Herr, D.R., Harris, G.L., Joiner, W.J., and Finley, K.D. Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors. PloS One 10, e0132768, 2015. PMCID: PMC4504520.

Keene, A.C. and Joiner, W.J. Neurodegeneration: paying it off with sleep. Curr Biol. 25, R234-6, 2015. PMCID: PMC4381801.

Puddifoot, C.A., Wu, M., Sung, R.J., and Joiner, W.J. Ly6h Regulates Trafficking of Alpha7 Nicotinic Acetylcholine Receptors and Nicotine-Induced Potentiation of Glutamatergic Signaling. J. Neurosci. 35, 3420-30, 2015. PMCID: PMC4339353.


Wu, M., Robinson, J.E., and Joiner, W.J. SLEEPLESS is a bi-functional regulator of excitability and cholinergic synaptic transmission. Curr Biol. 24, 621-9, 2014. PMCID: PMC4059605.

Heinrichsen, E.T., Zhang, H., Robinson, J.E., Ngo, J., Diop, S., Bodmer, R., Joiner, W.J., Metallo, C.M., and Haddad, G.G. Metabolic and Transcriptional Response to a High-Fat Diet in Drosophila melanogaster. Mol Metab. 23, 42-54, 2014. PMCID: PMC3929909.


Joiner, W.J., Friedman, E.B., Hung, H.T., Koh, K., Sowcik, M., Sehgal, A., and Kelz, M.B. Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genet. 9, e1003605, 2013 (with accompanying editorial). PMCID: PMC3764144.


Dean, T., Xu, R., Joiner, W.J., Sehgal, A., and Hoshi, T. Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K+ channels. J. Neurosci. 3, 11387-95, 2011. PMCID: PMC3183472.


Friedman, E.B., Sun, Y., Moore, J.T., Hung, H.-T., Meng, Q.C., Perera, P., Joiner, W.J., Thomas, S.J., Eckenhoff, R.G., Sehgal, A., and Kelz, M.B. A Conserved Behavioral State Barrier Impedes Transitions Between Anesthetic-Induced Unconsciousness and Wakefulness Both in Mice and Flies. PLoS ONE 5, e11903, 2010. PMCID: PMC2912772.

*Wu, M.N., *Joiner, W.J., Dean, T., Yue, Z., Smith, C.J., Chen, D., Hoshi, T., Sehgal, A., and Koh, K. SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker. Nat Neurosci. 13, 69-75, 2010. PMCID: PMC2842941. (*co-first author)


*Koh, K., *Joiner, W.J., *Wu, M.N., Yue, Z., Smith, C.J., and Sehgal, A. Identification of SLEEPLESS, a sleep-promoting factor.  Science 321, 372-6 2008. PMCID: PMC2771549. (*co-first author)

Wu, M.N., Koh, K., Yue, Z., Joiner, W.J. and Sehgal, A. A Genetic Screen for Sleep and Circadian Mutants Reveals Mechanisms Underlying Regulation of Sleep in Drosophila. Sleep 31, 465-472, 2008. PMCID: PMC2279757.


Sehgal, A., Joiner, W., Crocker, A., Koh, K., Sathyanarayanan, S., Fang, Y., Wu, M., Williams, J.A., and Zheng, X. Molecular analysis of sleep:wake cycles in Drosophila. Cold Spring Harbor Symp. Quant. Biol. on Clocks and Rhythms 72, 557-64, 2007.


Joiner, W.J., Crocker, A., White, B.H., and Sehgal, A. Sleep in Drosophila is regulated by adult mushroom bodies. Nature 441, 757-60, 2006.

Yuan, Q., Joiner, W.J., and Sehgal, A. A Sleep-promoting Role for the Drosophila Serotonin Receptor 1A. Curr. Biol. 16, 1051-62, 2006.


Zhang Y, Joiner W.J., Bhattacharjee, A, Rassendren, F., Magoski, N.S., and Kaczmarek, L.K. The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior. J. Biol. Chem. 279, 52324-52330, 2004.


*Bhattacharjee, A., *Joiner, W.J., Wu, M., Yang, Y., Sigworth, F.J., and Kaczmarek, L.K. Slick, a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATP. J. Neurosci. 23, 11681-91, 2003. (*co-first author)

Hoffman J.F, Joiner W., Nehrke, K., Potapova, O., Foye, K., and Wickrema, A. The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. Proc. Natl. Acad. Sci. U S A. 100, 7366-71, 2003. PMCID: PMC165881.

Joiner, W.J., Basavappa, S., Vidyasagar, S., Nehrke, K., Krishnan, S., Binder, H.J., Boulpaep, E.L., and Rajendran, V.M. Active K+ secretion Through Multiple Types of KCa Channels and Regulation by IKCa Channels in Rat Proximal Colon. Am J. Physiol. (Gastrointest Liver Physiol.) 285, G185-96, 2003.


Joiner, W.J., Khanna, R., Schlichter, L.C., and Kaczmarek, L.K. Calmodulin Regulates Assembly and Trafficking of SK4/IK1 Ca2+-activated K+ Channels. J. Biol. Chem. 276, 37980-37985, 2001.

White, B.H., Osterwalder, T.P., Yoon, K.S., Joiner, W.J., Whim, M.D., Kaczmarek, L.K., and Keshishian, H. Targeted attenuation of electrical activity in Drosophila using a genetically modified K+ channel. Neuron 31, 699-711, 2001.


Khanna, R., Chang, M., Joiner, W.J., Kaczmarek, L.K., and Schlichter, L.C. hSK4/hIK1, a calmodulin-binding KCa channel in human T lymphocytes. Roles in proliferation and volume regulation. J. Biol. Chem. 274, 14838-14849, 1999.


Joiner, W.J., Tang, M.D., Wang, L.-Y., Gan, L., Dworetzky, S.I., Boissard, C.G., Gribkoff, V.K., and Kaczmarek, L.K. Formation of intermediate conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nature Neurosci. 1, 462-468, 1998.


Joiner, W.J., Wang, L.-Y., Tang, M., and Kaczmarek, L.K. hSK4, a member of a novel  subfamily of calcium-activated potassium channels. Proc. Natl. Acad. Sci. USA 94, 11013-11018, 1997. PMCID: PMC23566.


Ketchum, K.A., Joiner, W.J., Sellers, A.J., Kaczmarek, L.K., and Goldstein, S.A.N. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 376, 690-695, 1995.


McCormack, K., Joiner, W.J., and Heinemann, S.H. Characterization of the Activating Structural Rearrangements in Voltage-Dependent Shaker K+ Channels. Neuron 12, 301-315, 1994.


Wetterau, J.R., Combs, K.A., Spinner, S.N., Joiner, B.J. Protein disulfide isomerase is a component of the microsomal triglyceride  transfer protein complex. J. Biol. Chem. 265, 9801-9807, 1990.