Joiner Lab
Publications by William Joiner (* co-first author but listed second)
2016
Joiner, W.J. Unraveling the evolutionary determinants of sleep. Curr Biol. 26, R1073–R1087, 2016.
http://www.cell.com/current-biology/comments/S0960-9822(16)31013-2
Barekat, A., Gonzalez, A., Mauntz, R.E., Kotzebue, R.W., Molina, B., El-Macharrafie, N., Conner, C.J., Garza, S., Melkani, G.C., Joiner, W.J., Lipinski, M.M., Finley, K.D., and Ratliff, E.P. Using Drosophila as an integrated model to study mild repetitive traumatic brain injury. Sci Rep 6, 25252, 2016.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855207/pdf/srep25252.pdf
Landgraf, D., Joiner, W.J., McCarthy, M.J., Kiessling, S., Barandas, R., Young, J.W., Cermakian, N., and Welsh, D.K. The Mood Stabilizer Valproic Acid Opposes the Effects of Dopamine on Circadian Rhythms. Neuropharmacology 107, 262-270, 2016.
Wu, M., Liu, C.Z., and Joiner, W.J. Structural analysis and deletion mutagenesis define regions of QUIVER/SLEEPLESS that are responsible for interactions with Shaker-type potassium channels and nicotinic acetylcholine receptors. Plos One 11: e0148215, 2016.
Robinson, J.E., Paluch, J., Dickman, D.K., and Joiner, W.J. ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity.
Nat Commun. 7:10512, 2016. PMCID: PMC4737855.
http://www.nature.com/ncomms/2016/160127/ncomms10512/pdf/ncomms10512.pdf
2015
Seidner, G.A., Robinson, J.E., Wu, M., Worden, K., Masek, P., Roberts, S.W., Keene, A.C., and Joiner, W.J. Identification of neurons with a privileged role in sleep homeostasis in Drosophila melanogaster. Curr Biol. 25, 2928-2938, 2015. PMCID: PMC4654679.
http://www.sciencedirect.com/science/article/pii/S0960982215012348
Wu, M., Puddifoot, C.A., Taylor, P., and Joiner, W.J. Mechanisms of Inhibition and Potentiation of α4β2 Nicotinic Acetylcholine Receptors by Members of the Ly6 Protein Family. J. Biol. Chem. 290, 24509-18, 2015. PMCID: PMC4591831.
http://www.ncbi.nlm.nih.gov/pubmed/26276394
Zhang, S., Ross, K.D., Seidner, G.A., Gorman, M.R., Poon, T.H., Wang, X., Keithley, E.M., Lee, P.N., Martindale, M.Q., Joiner, W.J., and Hamilton, B.A. Nmf9 encodes a highly conserved protein important to neurological function in mice and flies. PLoS Genet. 11, e1005344, 2015. PMCID: PMC4488434.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488434/
Ratliff, E.P., Mauntz, R.E., Kotzebue, R.W., Gonzalez, A., Achal, M., Barekat, A., Finley, K.A., Sparhawk, J.M., Robinson, J.E., Herr, D.R., Harris, G.L., Joiner, W.J., and Finley, K.D. Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors. PloS One 10, e0132768, 2015. PMCID: PMC4504520.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132768
Keene, A.C. and Joiner, W.J. Neurodegeneration: paying it off with sleep. Curr Biol. 25, R234-6, 2015. PMCID: PMC4381801.
http://www.ncbi.nlm.nih.gov/pubmed/25784043
Puddifoot, C.A., Wu, M., Sung, R.J., and Joiner, W.J. Ly6h Regulates Trafficking of Alpha7 Nicotinic Acetylcholine Receptors and Nicotine-Induced Potentiation of Glutamatergic Signaling. J. Neurosci. 35, 3420-30, 2015. PMCID: PMC4339353.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339353/
2014
Wu, M., Robinson, J.E., and Joiner, W.J. SLEEPLESS is a bi-functional regulator of excitability and cholinergic synaptic transmission. Curr Biol. 24, 621-9, 2014. PMCID: PMC4059605.
http://www.sciencedirect.com/science/article/pii/S0960982214001948
Heinrichsen, E.T., Zhang, H., Robinson, J.E., Ngo, J., Diop, S., Bodmer, R., Joiner, W.J., Metallo, C.M., and Haddad, G.G. Metabolic and Transcriptional Response to a High-Fat Diet in Drosophila melanogaster. Mol Metab. 23, 42-54, 2014. PMCID: PMC3929909.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929909/
2013
Joiner, W.J., Friedman, E.B., Hung, H.T., Koh, K., Sowcik, M., Sehgal, A., and Kelz, M.B. Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genet. 9, e1003605, 2013 (with accompanying editorial). PMCID: PMC3764144.
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003605
2011
Dean, T., Xu, R., Joiner, W.J., Sehgal, A., and Hoshi, T. Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K+ channels. J. Neurosci. 3, 11387-95, 2011. PMCID: PMC3183472.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183472/
2010
Friedman, E.B., Sun, Y., Moore, J.T., Hung, H.-T., Meng, Q.C., Perera, P., Joiner, W.J., Thomas, S.J., Eckenhoff, R.G., Sehgal, A., and Kelz, M.B. A Conserved Behavioral State Barrier Impedes Transitions Between Anesthetic-Induced Unconsciousness and Wakefulness Both in Mice and Flies. PLoS ONE 5, e11903, 2010. PMCID: PMC2912772.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912772/
*Wu, M.N., *Joiner, W.J., Dean, T., Yue, Z., Smith, C.J., Chen, D., Hoshi, T., Sehgal, A., and Koh, K. SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker. Nat Neurosci. 13, 69-75, 2010. PMCID: PMC2842941. (*co-first author)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842941/
2008
*Koh, K., *Joiner, W.J., *Wu, M.N., Yue, Z., Smith, C.J., and Sehgal, A. Identification of SLEEPLESS, a sleep-promoting factor. Science 321, 372-6 2008. PMCID: PMC2771549. (*co-first author)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771549/
Wu, M.N., Koh, K., Yue, Z., Joiner, W.J. and Sehgal, A. A Genetic Screen for Sleep and Circadian Mutants Reveals Mechanisms Underlying Regulation of Sleep in Drosophila. Sleep 31, 465-472, 2008. PMCID: PMC2279757.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279757/
2007
Sehgal, A., Joiner, W., Crocker, A., Koh, K., Sathyanarayanan, S., Fang, Y., Wu, M., Williams, J.A., and Zheng, X. Molecular analysis of sleep:wake cycles in Drosophila. Cold Spring Harbor Symp. Quant. Biol. on Clocks and Rhythms 72, 557-64, 2007.
http://www.ncbi.nlm.nih.gov/pubmed/18419315
2006
Joiner, W.J., Crocker, A., White, B.H., and Sehgal, A. Sleep in Drosophila is regulated by adult mushroom bodies. Nature 441, 757-60, 2006.
http://www.ncbi.nlm.nih.gov/pubmed/16760980
Yuan, Q., Joiner, W.J., and Sehgal, A. A Sleep-promoting Role for the Drosophila Serotonin Receptor 1A. Curr. Biol. 16, 1051-62, 2006.
http://www.sciencedirect.com/science/article/pii/S096098220601493X
2004
Zhang Y, Joiner W.J., Bhattacharjee, A, Rassendren, F., Magoski, N.S., and Kaczmarek, L.K. The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior. J. Biol. Chem. 279, 52324-52330, 2004.
http://www.jbc.org/content/279/50/52324.full?sid=b1358521-487f-49ed-bb64-c17f6d897b75
2003
*Bhattacharjee, A., *Joiner, W.J., Wu, M., Yang, Y., Sigworth, F.J., and Kaczmarek, L.K. Slick, a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATP. J. Neurosci. 23, 11681-91, 2003. (*co-first author)
http://www.jneurosci.org/content/23/37/11681.long
Hoffman J.F, Joiner W., Nehrke, K., Potapova, O., Foye, K., and Wickrema, A. The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. Proc. Natl. Acad. Sci. U S A. 100, 7366-71, 2003. PMCID: PMC165881.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165881/
Joiner, W.J., Basavappa, S., Vidyasagar, S., Nehrke, K., Krishnan, S., Binder, H.J., Boulpaep, E.L., and Rajendran, V.M. Active K+ secretion Through Multiple Types of KCa Channels and Regulation by IKCa Channels in Rat Proximal Colon. Am J. Physiol. (Gastrointest Liver Physiol.) 285, G185-96, 2003.
http://ajpgi.physiology.org/content/285/1/G185
2001
Joiner, W.J., Khanna, R., Schlichter, L.C., and Kaczmarek, L.K. Calmodulin Regulates Assembly and Trafficking of SK4/IK1 Ca2+-activated K+ Channels. J. Biol. Chem. 276, 37980-37985, 2001.
http://www.jbc.org/content/276/41/37980.full?sid=0fb1a274-0112-4576-b92d-22488abbdb9a
White, B.H., Osterwalder, T.P., Yoon, K.S., Joiner, W.J., Whim, M.D., Kaczmarek, L.K., and Keshishian, H. Targeted attenuation of electrical activity in Drosophila using a genetically modified K+ channel. Neuron 31, 699-711, 2001.
http://www.sciencedirect.com/science/article/pii/S0896627301004159
1999
Khanna, R., Chang, M., Joiner, W.J., Kaczmarek, L.K., and Schlichter, L.C. hSK4/hIK1, a calmodulin-binding KCa channel in human T lymphocytes. Roles in proliferation and volume regulation. J. Biol. Chem. 274, 14838-14849, 1999.
http://www.jbc.org/content/274/21/14838.long
1998
Joiner, W.J., Tang, M.D., Wang, L.-Y., Gan, L., Dworetzky, S.I., Boissard, C.G., Gribkoff, V.K., and Kaczmarek, L.K. Formation of intermediate conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nature Neurosci. 1, 462-468, 1998.
http://www.ncbi.nlm.nih.gov/pubmed/10196543
1997
Joiner, W.J., Wang, L.-Y., Tang, M., and Kaczmarek, L.K. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc. Natl. Acad. Sci. USA 94, 11013-11018, 1997. PMCID: PMC23566.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC23566/
1995
Ketchum, K.A., Joiner, W.J., Sellers, A.J., Kaczmarek, L.K., and Goldstein, S.A.N. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 376, 690-695, 1995.
http://www.ncbi.nlm.nih.gov/pubmed/7651518
1994
McCormack, K., Joiner, W.J., and Heinemann, S.H. Characterization of the Activating Structural Rearrangements in Voltage-Dependent Shaker K+ Channels. Neuron 12, 301-315, 1994.
http://www.ncbi.nlm.nih.gov/pubmed/8110460
1990
Wetterau, J.R., Combs, K.A., Spinner, S.N., Joiner, B.J. Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex. J. Biol. Chem. 265, 9801-9807, 1990.